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Older adults with food-cobalamin malabsorption , where the stomach acid needed to release B12 from food has dropped with age

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Aged mice treated with NNMT inhibitors demonstrated approximately 70% greater peak torque (contractile force) in injured muscles compared to untreated controls

The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default